|
̹ м Obesity(IF: 9.298, Q1, ش о 5.6%) 6 13 ¶ ƴ.( : Gi-coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals)
索 ν к ְ ְų ν ϴµ, ָ ϴ ν ǥμ ϴ ſ ߿ ̴.
â ̹ G ܹ- ü GPR41 ȭչ ȭ ϴ GPR41 ɷ Ű, ̸ ִٴ .
GPR41 amlodipine-ΰ dihydropyridine Įθ Ca2+ Ű, Ųٴ ´. Ư, Ca2+/calmodulin-dependent protein kinase type II, cyclic AMP-responsive element-binding protein, mitogen-activated protein kinase(p38) ΰ ֿ ۿ Ѵٴ Ըߴ.
, 1 索(streptozotocin ) 2 索( ) 콺 GPR41 ȭչ 索 汸 ν ġ Ӹ ƴ϶ ݱ glycogen Է ߴ.
â GPR41 ȭչ ɷ ȿ 索 ſ ǹѴ١, GPR41 Űϴ ȯ ȿ ۿ , ȯ ġ ǥμ Ÿ缺 ư Ѵ١ .
, ̹ бź(ѱ) ߰߿ ƴ.